PRSS1 anticorps

N° du produit ABIN7101954

L’anticorps Souris Monoclonal anti-PRSS1 a été validé pour EIA. Il convient pour détecter PRSS1 dans des échantillons de Humain.

Aperçu rapide pour PRSS1 anticorps (ABIN7101954)

Antigène: PRSS1 (Protease, serine, 1 (Trypsin 1) (PRSS1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PRSS1 est non-conjugé

Application: Enzyme Immunoassay (EIA)

Clone: 401

Détail du produit anti-PRSS1 anticorps

Specificité: Human pancreatic trypsin. Recognizes specifically pancreatic trypsin. Does not cross react with Pancreatic Chymotrypsin.

Purification: Protein G affinity chromatography.

Immunogène: Purified human pancreatic trypsin

Isotype: IgG2b

Information d'application

Indications d'application: ELISA: May be used in immunoassays to detect and quantitate Pancreatic Trypsin.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL (OD 280 nm)

Buffer: PBS, pH 7.4 without preservatives.

Agent conservateur: Without preservative

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody prior to reconstitution at -20 °C. Following reconstitution the antibody can be stored at 2-8 °C for one month or at -20 °C for longer.

Détails sur PRSS1

Antigène: PRSS1 (Protease, serine, 1 (Trypsin 1) (PRSS1))

Autre désignation: Trypsin-1 / PRSS1

Sujet: The human pancreas secretes three different isoforms of the inactive trypsinogen into the small intestine, namely cationic trypsinogen, anionic trypsinogen (the two major isoforms) and mesotrypsinogen (a minor isoform). In the small intestine, each isoform is cleaved by Enterokinase into its active form, Trypsin-1, Trypsin-2 and Trypsin-3, respectively. All trypsins are members of the serine protease trypsin family. The activated trypsins go on to activate other protease zymogens and play a role in the autoactivation of trypsinogens. This suggests an important role for trypsins in digestion. Mutations in the gene encoding Trypsin-1 that stimulate its activity are associated with autosomal dominant hereditary pancreatitis (HCP), also known as chronic pancreatitis (CP), a disease characterized by persistent, severe abdominal pain due to calcifications of the parenchyma, pancreatic stones, cysts and pancreatic head enlargement. Trypsin-3, also known as Trypsin-4, is expressed in the brain in addition to the pancreas.Synonyms: Beta-trypsin, Cationic trypsinogen, Serine protease 1, TRP1, TRY1, TRYP1, Trypsin I

ID gène: 5644

NCBI Accession: NP_002760

UniProt: P07477